Objective and Impact Statement. There is a need to develop platforms delineating inflammatory biology of the distal human lung. We describe a platform technology approach to detect in situ enzyme activity and observe drug inhibition in the distal human lung using a combination of matrix metalloproteinase (MMP) optical reporters. fibered confocal fluorescence microscopy (FCFM). https://www.spidertattooz.com/OPI-Infinite-Shine-All-Your-Dreams-in-Vending-Machines-ISLT84-p27376/