Abstract Background HER2-positive patients comprise approximately 20% of breast cancer cases. with HER2-targeted therapy significantly improving progression-free and overall survival. However. subsequent reprogramed tumor progression due to PI3K signaling pathway activation by PIK3CA mutations and/or PTEN-loss cause anti-HER2 resistance. https://ashleyshomestores.shop/product-category/7-piece-sectional-with-audio-console/